The foundation stone of this grand medical institution was laid by the Royal Highness, the Prince of Wales, in 1906, during his second visit to India for his Coronation Durbar as King Emperor. King gave his consent to establish the institution and to designate it by his name. Since then, the institution has been dedicated to excellent medical education, unparalleled medical ethics, groundbreaking research, and exceptional patient care.

On 16th September 2002 an Act was passed by the Government of Uttar Pradesh resulting in a major milestone in change in the history of the institution in converting and upgrading it as Chhatrapati Shahuji Maharaj Medical University.

Later in October 2003 the name of the medical university was reverted from C.S.M. Medical University to K.G. Medical University. K.G. Medical University has contributed immensely in the education and training of thousands of graduate and post-graduates who have brought glory and laurels to their Alma mater by academic and professional excellence.